Gene name: | ANG; |
Protein name: | Angiogenin; |
Alternative: | Ribonuclease 5(RNase 5); |
Organism: | Pig (Sus scrofa). |
Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
Subcellular Location: | Secreted |
Sequence length: | 123 |
Sequence: | |
50: | KDEDRYTHFL | TQHYDAKPKG | RDGRYCESIM | KQRGLTRPCK | EVNTFIHGTR | |
100: | NDIKAICNDK | NGEPYNNFRR | SKSPFQITTC | KHKGGSNRPP | CGYRATAGFR | |
123: | TIAVACENGL | PVHFDESFII | TSQ |
3D Structure: | N/A |
Pfam: | PF00074 |
SMR: | P31346 |
Uniprot: | P31346 |