Gene name: | Ang(Ang1;Rnase5;Rnase5a); |
Protein name: | Angiogenin; |
Alternative: | Angiogenin-1;Ribonuclease 5(RNase 5); |
Organism: | Mouse (Mus musculus). |
Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
Subcellular Location: | Secreted |
Sequence length: | 145 |
Sequence: | |
50: | MAISPGPLFL | IFVLGLVVIP | PTLAQDDSRY | TKFLTQHHDA | KPKGRDDRYC | |
100: | ERMMKRRSLT | SPCKDVNTFI | HGNKSNIKAI | CGANGSPYRE | NLRMSKSPFQ | |
145: | VTTCKHTGGS | PRPPCQYRAS | AGFRHVVIAC | ENGLPVHFDE | SFFSL |
3D Structure: | N/A |
SMR: | P21570 |
STRING: | 10090.ENSMUSP00000067434 |
KEGG: | mmu:11727 |
UniGene: | Mm.202665 |
Pfam: | PF00074 |
String: | P21570 |
Uniprot: | P21570 |