| Gene name: | Ang(Ang1;Rnase5;Rnase5a); |
| Protein name: | Angiogenin; |
| Alternative: | Angiogenin-1;Ribonuclease 5(RNase 5); |
| Organism: | Mouse (Mus musculus). |
| Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
| Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
| Subcellular Location: | Secreted |
| Sequence length: | 145 |
| Sequence: | |
| 50: | MAISPGPLFL | IFVLGLVVIP | PTLAQDDSRY | TKFLTQHHDA | KPKGRDDRYC | |
| 100: | ERMMKRRSLT | SPCKDVNTFI | HGNKSNIKAI | CGANGSPYRE | NLRMSKSPFQ | |
| 145: | VTTCKHTGGS | PRPPCQYRAS | AGFRHVVIAC | ENGLPVHFDE | SFFSL |
| 3D Structure: | N/A |
| SMR: | P21570 |
| STRING: | 10090.ENSMUSP00000067434 |
| KEGG: | mmu:11727 |
| UniGene: | Mm.202665 |
| Pfam: | PF00074 |
| String: | P21570 |
| Uniprot: | P21570 |