| Gene name: | ANG(RNASE5); |
| Protein name: | Angiogenin; |
| Alternative: | Ribonuclease 5(RNase 5); |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
| Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
| Subcellular Location: | Secreted |
| Sequence length: | 147 |
| Sequence: | |
| 50: | MVMGLGVLLL | VFVLGLGLTP | PTLAQDNSRY | THFLTQHYDA | KPQGRDDRYC | |
| 100: | ESIMRRRGLT | SPCKDINTFI | HGNKRSIKAI | CENKNGNPHR | ENLRISKSSF | |
| 147: | QVTTCKLHGG | SPWPPCQYRA | TAGFRNVVVA | CENGLPVHLD | QSIFRRP |
| 3D Structure: | N/A |
| MIM: | 105850 |
| SMR: | P03950 |
| KEGG: | hsa:283 |
| String: | P03950 |
| Pfam: | PF00074 |
| STRING: | 9606.ENSP00000336762 |
| UniGene: | Hs.283749 |
| Uniprot: | P03950 |