Gene name: | ANG(RNASE5); |
Protein name: | Angiogenin; |
Alternative: | Ribonuclease 5(RNase 5); |
Organism: | Human (Homo sapiens). |
Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
Subcellular Location: | Secreted |
Sequence length: | 147 |
Sequence: | |
50: | MVMGLGVLLL | VFVLGLGLTP | PTLAQDNSRY | THFLTQHYDA | KPQGRDDRYC | |
100: | ESIMRRRGLT | SPCKDINTFI | HGNKRSIKAI | CENKNGNPHR | ENLRISKSSF | |
147: | QVTTCKLHGG | SPWPPCQYRA | TAGFRNVVVA | CENGLPVHLD | QSIFRRP |
3D Structure: | N/A |
MIM: | 105850 |
SMR: | P03950 |
KEGG: | hsa:283 |
String: | P03950 |
Pfam: | PF00074 |
STRING: | 9606.ENSP00000336762 |
UniGene: | Hs.283749 |
Uniprot: | P03950 |