| Gene name: | ANG; |
| Protein name: | Angiogenin; |
| Alternative: | Ribonuclease A; |
| Organism: | Chicken (Gallus gallus). |
| Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
| Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
| Subcellular Location: | Secreted |
| Sequence length: | 139 |
| Sequence: | |
| 50: | MAMSSLWWTA | ILLLALTVSM | CYGVPTYQDF | LRTHVDFPKT | SFPNIAAYCN | |
| 100: | VMMVRRGINV | HGRCKSLNTF | VHTDPRNLNT | LCINQPNRAL | RTTQQQLPVT | |
| 139: | DCKLIRSHPT | CSYTGNQFNH | RVRVGCWGGL | PVHLDGTFP |
| 3D Structure: | N/A |
| Pfam: | PF00074 |
| UniGene: | Gga.703 |
| KEGG: | gga:396194 |
| Uniprot: | P27043 |