Gene name: | ANG; |
Protein name: | Angiogenin; |
Alternative: | Ribonuclease A; |
Organism: | Chicken (Gallus gallus). |
Sub Unit: | Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. |
Function: | May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
Subcellular Location: | Secreted |
Sequence length: | 139 |
Sequence: | |
50: | MAMSSLWWTA | ILLLALTVSM | CYGVPTYQDF | LRTHVDFPKT | SFPNIAAYCN | |
100: | VMMVRRGINV | HGRCKSLNTF | VHTDPRNLNT | LCINQPNRAL | RTTQQQLPVT | |
139: | DCKLIRSHPT | CSYTGNQFNH | RVRVGCWGGL | PVHLDGTFP |
3D Structure: | N/A |
Pfam: | PF00074 |
UniGene: | Gga.703 |
KEGG: | gga:396194 |
Uniprot: | P27043 |